A to Z / Longevity
MOTS-c
Also known as Mitochondrial ORF of the 12S rRNA type-c.
What it is
MOTS-c is a mitochondrial-derived peptide: a short peptide encoded not by the cell nucleus but by mitochondrial DNA. Its discovery was an important scientific finding: mitochondria were not thought to produce signalling peptides that act on the rest of the body. Research so far is in mice, there are no human efficacy trials yet, and it is not approved as a medicine.
It is one of the most discussed compounds in longevity research.
What the full entry covers
The book carries the rest of this entry:
- Where the research stands, with every claim cited
- What people commonly ask, and what the research shows so far
- Dosing in four labelled bands, described and not recommended
- Side effects, serious risks, cautions and interactions
- Questions to discuss with your doctor
- How it compares with SS-31, Humanin, Epitalon, FOXO4-DRI
Related entries
A certificate of analysis tells you what is in a vial. The evidence rating above tells you whether the compound has been shown to work in humans. Neither answers the other's question. How to read a certificate of analysis.
This page describes what is known and not known about MOTS-c. It is not medical advice and not a recommendation to use it.