The Encyclopedia of Peptides

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Humanin

Also known as HN, HNG (analogue).

Best known for The first mitochondrial-derived peptide discovered
Evidence★☆☆☆☆
Safety dataLargely unknown
Route Injectable
United StatesNot approved
AustraliaNot listed by name; unapproved therapeutic good
as at 16 September 2026

What it is

Humanin is a 24-amino-acid peptide encoded by mitochondrial DNA: the first mitochondrial-derived peptide identified, found in 2001 during research into Alzheimer's disease. MOTS-c came later from the same line of enquiry. Humanin is at the laboratory and animal research stage, with no human efficacy trials yet, and it is not approved.

What the full entry covers

The book carries the rest of this entry:

Related entries

A certificate of analysis tells you what is in a vial. The evidence rating above tells you whether the compound has been shown to work in humans. Neither answers the other's question. How to read a certificate of analysis.

This page describes what is known and not known about Humanin. It is not medical advice and not a recommendation to use it.