A to Z / Longevity
FOXO4-DRI
Also known as FOXO4-p53 interfering peptide, proxofim.
What it is
FOXO4-DRI is a synthetic senolytic peptide, designed to selectively clear senescent cells: damaged cells that stop dividing, resist normal cell death and secrete inflammatory signals. DRI stands for D-Retro-Inverso, a modification that resists breakdown. It is at the animal research stage, with no human trials yet, and it is not approved.
What the full entry covers
The book carries the rest of this entry:
- Where the research stands, with every claim cited
- What people commonly ask, and what the research shows so far
- Dosing in four labelled bands, described and not recommended
- Side effects, serious risks, cautions and interactions
- Questions to discuss with your doctor
- How it compares with Epitalon, MOTS-c, Humanin, SS-31
Related entries
A certificate of analysis tells you what is in a vial. The evidence rating above tells you whether the compound has been shown to work in humans. Neither answers the other's question. How to read a certificate of analysis.
This page describes what is known and not known about FOXO4-DRI. It is not medical advice and not a recommendation to use it.