A to Z / Sexual health

Kisspeptin-10

Also known as KP-10, metastin fragment.

Best known for The upstream switch for reproductive hormones

Evidence★★☆☆☆

Safety dataPoorly characterised

Route Injectable · nasal

United StatesInvestigational; current 503A Category 2 substance (29 September 2023)

AustraliaNot listed by name; unapproved therapeutic good

as at 16 September 2026

What it is

Kisspeptin is the peptide that sits at the top of the reproductive hormone cascade: it triggers GnRH release, which triggers LH and FSH, which drive testosterone and oestrogen. Kisspeptin-10 is a short active fragment. Its discovery substantially rewrote the understanding of how puberty is initiated. It is investigational in the United States, with small human physiology studies, and not approved anywhere.

What the full entry covers

The book carries the rest of this entry:

Where the research stands, with every claim cited
What people commonly ask, and what the research shows so far
Dosing in four labelled bands, described and not recommended
Side effects, serious risks, cautions and interactions
Questions to discuss with your doctor
How it compares with PT-141, Gonadorelin, hCG

Related entries

PT-141The approved libido medicine, also used outside prescription · Evidence ★★★★☆
GonadorelinThe TRT adjunct that isn't hCG · Evidence ★★★★☆
hCGA proven fertility medicine, not supported for weight loss · Evidence ★★★★☆

A certificate of analysis tells you what is in a vial. The evidence rating above tells you whether the compound has been shown to work in humans. Neither answers the other's question. How to read a certificate of analysis.

This page describes what is known and not known about Kisspeptin-10. It is not medical advice and not a recommendation to use it.