The Encyclopedia of Peptides

A to Z / Growth hormone

Sermorelin

Also known as GRF 1-29, Geref, GHRH(1-29).

Best known for The GHRH analogue once approved, now compounded
Evidence★★★★☆
Safety dataModerately characterised
Route injectable (subcutaneous)
United StatesPreviously approved; now compounded
AustraliaSchedule 4; captured by Appendix D cl.5 class entry (GHRHs)
as at 16 September 2026

What it is

Sermorelin is the first 29 amino acids of natural growth hormone releasing hormone: the shortest fragment that retains full activity. It was FDA-approved as Geref for diagnosing and treating growth hormone deficiency in children.{{CITE:fr-geref-2013}}

The manufacturer withdrew it from the US market in 2008.{{CITE:fr-geref-2013}} That withdrawal was commercial, not a safety action, a detail that is often misunderstood in both directions.{{CITE:fr-geref-2013}}{{CITE:fda-drugsfda-geref}}

Today it is the most commonly compounded growth hormone peptide in American anti-ageing clinics.

What the full entry covers

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Related entries

A certificate of analysis tells you what is in a vial. The evidence rating above tells you whether the compound has been shown to work in humans. Neither answers the other's question. How to read a certificate of analysis.

This page describes what is known and not known about Sermorelin. It is not medical advice and not a recommendation to use it.