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NAD+ and Precursors

Also known as NMN, nicotinamide mononucleotide, NR, nicotinamide riboside, NAD+ IV.

Best known for The longevity supplement popular across the peptide community

Evidence★★★☆☆

Safety dataModerately characterised

Route Oral · IV · injectable

United StatesNMN status contested; NR lawful as a supplement

AustraliaSupplement status varies; NMN restricted

as at 16 September 2026

What it is

NAD+ is a coenzyme, and NMN and NR are vitamin B3 derivatives that raise it. They have a substantial body of human trials showing they raise NAD+, while clinical benefit is still being studied. They are not peptides. They are included because they are central to the same longevity conversation, are available from the same suppliers, and are often discussed alongside MOTS-c and SS-31, and because it helps readers to know they are a different class.

What the full entry covers

The book carries the rest of this entry:

Where the research stands, with every claim cited
What people commonly ask, and what the research shows so far
Dosing in four labelled bands, described and not recommended
Side effects, serious risks, cautions and interactions
Questions to discuss with your doctor
How it compares with MOTS-c, SS-31, Glutathione, Carnosine

Related entries

MOTS-cThe flagship mitochondrial longevity peptide · Evidence ★☆☆☆☆
SS-31The mitochondrial peptide with modern human trials · Evidence ★★★☆☆
GlutathioneThe antioxidant tripeptide used in IV drips and skin-lightening injections · Evidence ★★☆☆☆
CarnosineThe muscle dipeptide used as an anti-glycation supplement · Evidence ★★★☆☆

A certificate of analysis tells you what is in a vial. The evidence rating above tells you whether the compound has been shown to work in humans. Neither answers the other's question. How to read a certificate of analysis.

This page describes what is known and not known about NAD+ and Precursors. It is not medical advice and not a recommendation to use it.