A to Z / Cosmetic / skin
Matrixyl 3000
Also known as Palmitoyl Tripeptide-1 + Palmitoyl Tetrapeptide-7.
Best known for The two-peptide upgrade found in most retail serums
Evidence★★★☆☆
Safety dataWell characterised
Route Topical
United StatesCosmetic ingredient: lawfully sold
AustraliaCosmetic ingredient: lawfully sold
as at 16 September 2026
What it is
Matrixyl 3000 is a combination of two peptides, Palmitoyl Tripeptide-1 and Palmitoyl Tetrapeptide-7. It is one of the most widely used anti-ageing actives in retail skincare, with human topical studies behind it, and it is a lawful cosmetic ingredient.
What the full entry covers
The book carries the rest of this entry:
- Where the research stands, with every claim cited
- What people commonly ask, and what the research shows so far
- Dosing in four labelled bands, described and not recommended
- Side effects, serious risks, cautions and interactions
- Questions to discuss with your doctor
- How it compares with Matrixyl, GHK-Cu, Argireline, Palmitoyl Tripeptide-1
Related entries
A certificate of analysis tells you what is in a vial. The evidence rating above tells you whether the compound has been shown to work in humans. Neither answers the other's question. How to read a certificate of analysis.
This page describes what is known and not known about Matrixyl 3000. It is not medical advice and not a recommendation to use it.