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Palmitoyl Tripeptide-1

Also known as Pal-GHK, palmitoyl oligopeptide.

Best known for The collagen-signalling half of Matrixyl 3000

Evidence★★★☆☆

Safety dataWell characterised

Route Topical

United StatesCosmetic ingredient: lawfully sold

AustraliaCosmetic ingredient: lawfully sold

as at 16 September 2026

What it is and what it does

Palmitoyl Tripeptide-1 is the GHK sequence, the same tripeptide as in GHK-Cu, attached to a fatty acid, and without the copper. It signals fibroblasts to produce collagen. It is a lawful cosmetic ingredient with human topical data behind it.{{CITE:aicis-cosmetics}}{{CITE:fda-cosmetics-authority}}

What the full entry covers

The book carries the rest of this entry:

Where the research stands, with every claim cited
What people commonly ask, and what the research shows so far
Dosing in four labelled bands, described and not recommended
Side effects, serious risks, cautions and interactions
Questions to discuss with your doctor
How it compares with Matrixyl 3000, Matrixyl, GHK-Cu, Decorinyl

Related entries

Matrixyl 3000The two-peptide upgrade found in most retail serums · Evidence ★★★☆☆
MatrixylOne of the best-evidenced cosmetic peptides · Evidence ★★★☆☆
GHK-CuSkin renewal and collagen support · Evidence ★★☆☆☆
DecorinylThe peptide that organises collagen rather than making more of it · Evidence ★★☆☆☆

A certificate of analysis tells you what is in a vial. The evidence rating above tells you whether the compound has been shown to work in humans. Neither answers the other's question. How to read a certificate of analysis.

This page describes what is known and not known about Palmitoyl Tripeptide-1. It is not medical advice and not a recommendation to use it.