The Encyclopedia of Peptides

A to Z / Cosmetic / skin

Argireline

Also known as Acetyl Hexapeptide-8, Acetyl Hexapeptide-3.

Best known for The expression-line peptide often called "topical Botox"
Evidence★★★☆☆
Safety dataWell characterised
Route topical
United StatesCosmetic ingredient: lawfully sold
AustraliaCosmetic ingredient: lawfully sold
as at 16 September 2026

What it is

Argireline is the trade name for Acetyl Hexapeptide-8: a six-amino-acid peptide found in a very large number of anti-wrinkle serums and creams. On an ingredients list it appears under that INCI name, or sometimes as Acetyl Hexapeptide-3, which is the same thing under older nomenclature.

It is an established cosmetic ingredient with small human topical trials behind it, and one of the few compounds in this book that are lawfully available in shops everywhere.

What the full entry covers

The book carries the rest of this entry:

Related entries

A certificate of analysis tells you what is in a vial. The evidence rating above tells you whether the compound has been shown to work in humans. Neither answers the other's question. How to read a certificate of analysis.

This page describes what is known and not known about Argireline. It is not medical advice and not a recommendation to use it.