The Encyclopedia of Peptides

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DSIP

Also known as Delta Sleep-Inducing Peptide, Emideltide.

Best known for The sleep peptide PCAC did not recommend in 2026
Evidence★☆☆☆☆
Safety dataLargely unknown
Route Injectable · nasal
United StatesNot approved; reviewed by PCAC July 2026 as Emideltide, outcome not published by FDA
AustraliaNot listed by name; unapproved therapeutic good
as at 16 September 2026

What it is

Delta Sleep-Inducing Peptide is a nine-amino-acid peptide isolated in the 1970s from rabbit brain during slow-wave sleep. It has a long but limited human research history. It is also called Emideltide, and under that name it was the single substance the FDA's Pharmacy Compounding Advisory Committee voted not to recommend in July 2026.

That is useful to know, because the compound available today as “DSIP” is the same one the committee reviewed and did not recommend under its other name.

What the full entry covers

The book carries the rest of this entry:

Related entries

A certificate of analysis tells you what is in a vial. The evidence rating above tells you whether the compound has been shown to work in humans. Neither answers the other's question. How to read a certificate of analysis.

This page describes what is known and not known about DSIP. It is not medical advice and not a recommendation to use it.