A to Z / Cosmetic / skin
Syn-Ake
Also known as Dipeptide Diaminobutyroyl Benzylamide Diacetate.
Best known for The "snake venom" wrinkle peptide
Evidence★★☆☆☆
Safety dataWell characterised
Route Topical
United StatesCosmetic ingredient: lawfully sold
AustraliaCosmetic ingredient: lawfully sold
as at 16 September 2026
What it is and what it does
Syn-Ake is a synthetic tripeptide modelled on waglerin-1, a component of temple viper venom. It contains no venom. It is a lawful cosmetic ingredient, widely used in skincare to soften expression lines.{{CITE:aicis-cosmetics}}{{CITE:fda-cosmetics-authority}}
What the full entry covers
The book carries the rest of this entry:
- Where the research stands, with every claim cited
- What people commonly ask, and what the research shows so far
- Dosing in four labelled bands, described and not recommended
- Side effects, serious risks, cautions and interactions
- Questions to discuss with your doctor
- How it compares with Argireline, SNAP-8, Leuphasyl, Matrixyl
Related entries
A certificate of analysis tells you what is in a vial. The evidence rating above tells you whether the compound has been shown to work in humans. Neither answers the other's question. How to read a certificate of analysis.
This page describes what is known and not known about Syn-Ake. It is not medical advice and not a recommendation to use it.