A to Z / Cosmetic / skin
Progeline
Also known as Trifluoroacetyl Tripeptide-2.
Best known for The jawline and sagging peptide
Evidence★★☆☆☆
Safety dataWell characterised
Route Topical
United StatesCosmetic ingredient: lawfully sold
AustraliaCosmetic ingredient: lawfully sold
as at 16 September 2026
What it is and what it does
Progeline is Trifluoroacetyl Tripeptide-2, a lawful cosmetic ingredient with limited human topical data so far.{{CITE:aicis-cosmetics}}{{CITE:fda-cosmetics-authority}} It is commonly discussed for sagging skin, jawline definition and loss of facial contour rather than for fine lines.
What the full entry covers
The book carries the rest of this entry:
- Where the research stands, with every claim cited
- What people commonly ask, and what the research shows so far
- Dosing in four labelled bands, described and not recommended
- Side effects, serious risks, cautions and interactions
- Questions to discuss with your doctor
- How it compares with Matrixyl, GHK-Cu, Decorinyl, Argireline
Related entries
A certificate of analysis tells you what is in a vial. The evidence rating above tells you whether the compound has been shown to work in humans. Neither answers the other's question. How to read a certificate of analysis.
This page describes what is known and not known about Progeline. It is not medical advice and not a recommendation to use it.