A to Z / Approved medicine
Plecanatide
Also known as Trulance.
Best known for The uroguanylin analogue for chronic constipation
Evidence★★★★★
Safety dataWell characterised
Route oral tablet, once daily
United StatesFDA approved
AustraliaSchedule 4: prescription only
as at 16 September 2026
What it is and what it does
Plecanatide is a 16-amino-acid analogue of uroguanylin, a natural gut hormone. It is an approved medicine, with phase-3 evidence, used to treat chronic idiopathic constipation and irritable bowel syndrome with constipation.
What the full entry covers
The book carries the rest of this entry:
- Where the research stands, with every claim cited
- What people commonly ask, and what the research shows so far
- Dosing in four labelled bands, described and not recommended
- Side effects, serious risks, cautions and interactions
- Questions to discuss with your doctor
- How it compares with Linaclotide, Teduglutide
Related entries
A certificate of analysis tells you what is in a vial. The evidence rating above tells you whether the compound has been shown to work in humans. Neither answers the other's question. How to read a certificate of analysis.
This page describes what is known and not known about Plecanatide. It is not medical advice and not a recommendation to use it.