A to Z / Approved medicine
Linaclotide
Also known as Linzess, Constella.
Best known for The oral peptide that works without being absorbed
Evidence★★★★★
Safety dataWell characterised
Route oral capsule, once daily on an empty stomach
United StatesFDA approved
AustraliaSchedule 4: prescription only
as at 16 September 2026
What it is and what it does
Linaclotide is a 14-amino-acid peptide that acts locally in the gut and is essentially not absorbed. It is an approved medicine for irritable bowel syndrome with constipation and chronic idiopathic constipation.
What the full entry covers
The book carries the rest of this entry:
- Where the research stands, with every claim cited
- What people commonly ask, and what the research shows so far
- Dosing in four labelled bands, described and not recommended
- Side effects, serious risks, cautions and interactions
- Questions to discuss with your doctor
- How it compares with Plecanatide, Teduglutide
Related entries
A certificate of analysis tells you what is in a vial. The evidence rating above tells you whether the compound has been shown to work in humans. Neither answers the other's question. How to read a certificate of analysis.
This page describes what is known and not known about Linaclotide. It is not medical advice and not a recommendation to use it.