A to Z / Growth hormone
MK-677
Also known as Ibutamoren, Nutrobal, MK-0677.
What it is
MK-677, ibutamoren, is an orally active growth hormone secretagogue. It is not a peptide: it is a small molecule designed to mimic ghrelin's action at the same receptor peptides like ipamorelin target.
It was investigated pharmaceutically and is not approved for any indication. It appears in this book because people encounter it alongside peptides, compare it with them and often find it through the same suppliers. Its oral activity is a large part of the interest: no injection is required.
It is also the most informative entry in this section, because it is the one compound in the growth hormone category that has been through a long, well-designed human trial. The volunteers in that trial produced a finding that is useful context for every other entry here.
What the full entry covers
The book carries the rest of this entry:
- Where the research stands, with every claim cited
- What people commonly ask, and what the research shows so far
- Dosing in four labelled bands, described and not recommended
- Side effects, serious risks, cautions and interactions
- Questions to discuss with your doctor
- How it compares with Ipamorelin, CJC-1295 (with DAC), Somatropin, GHRP-2
Related entries
A certificate of analysis tells you what is in a vial. The evidence rating above tells you whether the compound has been shown to work in humans. Neither answers the other's question. How to read a certificate of analysis.
This page describes what is known and not known about MK-677. It is not medical advice and not a recommendation to use it.