A to Z / Cosmetic / skin
Eyeseryl
Also known as Acetyl Tetrapeptide-5.
Best known for The under-eye puffiness peptide
Evidence★★☆☆☆
Safety dataWell characterised
Route Topical
United StatesCosmetic ingredient: lawfully sold
AustraliaCosmetic ingredient: lawfully sold
as at 16 September 2026
What it is and what it does
Eyeseryl is Acetyl Tetrapeptide-5, a four-amino-acid cosmetic peptide developed for under-eye puffiness and dark circles. It is a lawful cosmetic ingredient, with limited human topical data so far.
What the full entry covers
The book carries the rest of this entry:
- Where the research stands, with every claim cited
- What people commonly ask, and what the research shows so far
- Dosing in four labelled bands, described and not recommended
- Side effects, serious risks, cautions and interactions
- Questions to discuss with your doctor
- How it compares with GHK-Cu, Matrixyl, Argireline
Related entries
A certificate of analysis tells you what is in a vial. The evidence rating above tells you whether the compound has been shown to work in humans. Neither answers the other's question. How to read a certificate of analysis.
This page describes what is known and not known about Eyeseryl. It is not medical advice and not a recommendation to use it.